Dailymed lincomycin lincomycin hydrochloride powder, for. Lincomycin is a lincosamide antibiotic that comes from the actinomycete streptomyces lincolnensis. Lincomycin hydrochloride is effective against grampositive bacteria. Lincomycin hydrochloride market by product and end user. The chemical name for lincomycin hydrochloride is methyl 6,8dideoxy61methyltrans4propyll. The molecular formula of lincomycin hydrochloride is. Lincocin is indicated for the treatment of localized infections, such as abscesses, pneumonitis, and feline rhinotracheitis. Lincomycin hydrochloride, chemical structure, molecular. Similar discouraging reports regarding topical application of tetracycline in acne turned our attention to two of the few remaining effective antibiotics, lincomycin hydrochloride monohydrate lincocin and clindamycin cleocin. Sigmaaldrich offers a number of lincomycin hydrochloride monohydrate products. Lincomycin hydrochloride soluble powder is indicated for the control of necrotic enteritis caused by clostridium perfringens susceptible to lincomycin. W is the weight, in mg, of the portion of lincomycin hydrochloride taken to prepare the assay preparation. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin. Lincomycin definition of lincomycin by the free dictionary.
Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. The harmonized system hs code provided on this webpage are for information purposes only and are subject to change without notice. Overall summary of the scientific evaluation of lincocin. An antibiotic produced by streptomyces lincolnensis var. Administer at a dose rate of 250 mg of lincomycin per gallon of drinking water.
Other requirements where the label states that lincomycin hydrochloride is sterile,it meets the requirements for sterility and bacterial endotoxins under lincomycin injection. The molecular formula of lincomycin hydrochloride is c18h34n2o6s. Pdf stability studies of lincomycin hydrochloride in aqueous. It has a role as an antimicrobial agent and a bacterial metabolite. Lincomycin is a carbohydratecontaining antibiotic produced by the actinomyces streptomyces lincolnensis. Cleocin hclclindamycin hydrochloridecapsules, usp page 1. A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7hydroxy group with a chlorine atom with inversion of chirality. Assessing the depletion of lincomycin in feathers from treated broiler chickens. Lincocin lincomycin hydrochloride should be used with caution in those patients with a history of gastrointestinal disease. Lincocin sterile solution contains lincomycin hydrochloride which is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the. Other information text of r phrases mentioned in section 3 r43 may cause sensitization by skin contact. Lincocin lincomycin hcl pfizer medical information us. Side effects are rash, itching, nausea, vomiting, and diarrhea.
Product monograph prlincocin lincomycin injection usp. Lincocin products contain lincomycin hydrochloride, an antibiotic produced by. Lincomycin hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. P is the designated potency, in g of lincomycin per mg, of usp lincomycin hydrochloride rs. Lincomycin hydrochloride, brand name lincocin, is an injectable antibiotic used to treat serious infections that havent responded to other penicillins. Stability studies of lincomycin hydrochloride in aqueous solution and. Pdf purpose the purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used. Lincomycin hydrochloride api dmfs us drug master file. Where the label states that lincomycin hydrochloride must be subjected to further processing during the preparation of injectable dosage forms,it meets the requirements for bacterial endotoxins under lincomycin injection. Lincomycin hydrochloride anhydrous is the anhydrous hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete streptomyces lincolnensis with activity against grampositive cocci and anaerobic bacteria.
Close monitoring of liver and kidney function is necessary while receiving this medicine. Lincomycin first draft prepared by richard ellis, washington. The chemical name for lincomycin hydrochloride is methyl 6,8dideoxy61methyltrans4propyll2. List of drug master files dmf of lincomycin hydrochloride active pharmaceutical ingredient api submitted to the u. Lincocin lincomycin hydrochloride dose, indications. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg or 300 mg of clindamycin. Store at controlled room temperature 20 to 25c 68 to 77f see usp. In a glp conforming study, five groups of two pigs received oral doses of c lincomycin hydrochloride of 440 mg per animal per day by capsule hornish. Dailymed lincocin lincomycin hydrochloride injection, solution. Lincomycin hydrochloride zoetis oel twa 8hr 100gm3 estonia oel twa 2 mgm3 silicon dioxide, colloidal nf finland oel twa 5 mgm3 revision date. Lincomycin is a lincosamide antibiotic derived from bacteria streptomyces lincolnensis with activity against gram positive and anaerobic bacteria.
Lincomycin hydrochloride is freely soluble in water. Safety data sheet lincomycin hydrochloride injection, usp. Lincomycin binds to the 50s subunit of the bacterial ribosome resulting in the inhibition of protein synthesis and thereby produces bactericidal effects in susceptible organisms. In rats and mice, the acute oral ld50 of different pharmacopoeial and premix grades of lincomycin hydrochloride. In topical form, clindamycin is becoming very popular among clinical dermatologists. Lincomycin hydrochloride soluble powder for animal use. Lincocin sterile solution contains lincomycin hydrochloride which is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of streptomyces lincolnensis fam. Lincomycin article about lincomycin by the free dictionary. Lincocin lincomycin injection, usp to reduce the development of.
Lincomycin hydrochloride soluble powder indications and usage. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Jul 02, 2018 lincomycin hydrochloride pharmacokinetics absorption bioavailability. Directions for use lincomycin hydrochloride soluble powder dosage and administration. Find patient medical information for lincomycin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Buy 7epi lincomycin hydrochloride salt cas 26389844, a biochemical for proteomics research, from santa cruz. Do not use in horses intended for human consumption. Lincomycin inhibits bacterial protein synthesis by forming crosslinks within the peptidyl transferase loop region of the 23s rrna. Lincomycin side effects, dosage, interactions drugs. It should be used with caution due to the risk of diarrhoea. Stability studies of lincomycin hydrochloride in aqueous. Residue depletion study with 14clabelled lincomycin an equal number of 25 days old male and female hubbardcrosshubbard chicks were given water containing 14clincomycin hydrochloride, equivalent to 34 g of lincomycin free baseml specific activity 2. To the monograph and addendum prepared by the 54th and 58th meetings of the committee. It should be used only in cases where other medicines are less effective. Each ml of lincocin sterile solution contains lincomycin hydrochloride equivalent to lincomycin 300 mg. Nov 09, 2018 lincomycin is an antibiotic that fights bacteria.
Each ml containing lincomycin hydrochloride equivalent to lincomycin, 50 mg. In clinical studies, this dose rate provided an average of 3. Find patient medical information for lincomycin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Lincomycin hydrochloride, monohydrate msds special notice. The feces of mice were collected in the control stage day 0, with no treatment, modeling stage day 5, with the inoculation of lincomycin hydrochloride, treatment stage day 10, with the drug treatment, and recovery stage day 17, with no management. Lincomycin hydrochloride soluble powder is indicated for the treatment of swine dysentery bloody scours. Topically applied lincomycin for acne jama dermatology. To report adverse effects, access medical information, or obtain additional product. It is a carbohydratecontaining antibiotic, a sglycosyl compound, a monocarboxylic acid amide, a pyrrolidinecarboxamide and a lproline derivative. Following im administration of 600 mg in healthy adults, peak plasma concentrations of 9. Lincocin lincomycin hydrochloride product monograph. Lincocin lincomycin hcl how suppliedstorage and handling.
Lincomycin hydrochloride w as found to maintain its shelf life at 25c in sodium lactate hartmanns solution, 0. The purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used intravenous fluids at room temperature 25. To reduce the development of drugresistant bacteria and maintain the effectiveness of lincocin and other antibacterial drugs, lincocin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. May 16, 2019 lincomycin lincomycin hydrochloride powder, for solution out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Lincocin has caused rare, but sometimes fatal intestinal problems. Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids petra czarniak, michael boddy, bruce sunderland, jeff d hughes school of pharmacy, curtin university, perth, wa, australia purpose. Lincomycin hydrochloride soluble powder ireland oel twas 6 mgm3 2. Lincomycin is an antibiotic which is used in the treatment of infections caused by bacteria like streptococci, pneumococci, and staphylococci. Clindamycin is prepared as the hydrochloride salt of the base in 75, 150, and 300mg capsules and of the palmitate ester as a powder for pediatric suspension 75 mg5 ml. The lincomycin hydrochloride market has encountered significant development in the recent years and is anticipated to grow tremendously over the forecast period. Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding it is produced by streptomyces lincolnensis var.